Workers in the Department for Work and Pensions Mersey District Services Directorate are set to strike for three hours on Friday.
The action is in response to job transfers from local job centres to a central call centre.
The PCS union, which has called the strike, argues this will take workers away from the front line when unemployment is rocketing.
The workers who have been transferred are also set to join the strike.
The strike will be followed by an overtime ban and work to rule from Monday 2 April to Friday 6 April. It follows another strike against the transfers on 5 March.
Dave Owens, from the PCS DWP group executive, said, “The 5 March strike went really well, it was very well supported. We’re expecting this to be the same.
“People will all get to walk out together. It’s a great thing for us all to do.”