Bosses at Whittington Hospital in north London announced plans to close the A&E and wards last week.
They also want to sell hospital accommodation worth £17 million.
Bosses also plan to cap the number of births at the hospital at 4,000 a year.
The Whittington’s director of estates and facilities, Philip Lent, said that services that don’t “directly contribute to the corporate objectives” should be reviewed or cut.
More A&E closures are planned at Hammersmith and Charing Cross Hospitals in west London.
In 2010 campaigners stopped a plan to close A&E and maternity services at Whittington Hospital.